Fig. 1: Treatment algorithm from the EASO for individuals with obesity. | Nature Medicine

Fig. 1: Treatment algorithm from the EASO for individuals with obesity.

From: Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO)

Fig. 1

The treatment algorithm is based on the presence or absence of relevant obesity-related medical conditions. The algorithm is grounded in scientific evidence available up to 31 January 2025. Obesity management medications are listed in order of efficacy. Medications with equivalent or comparable efficacy are listed in the same position. Asterisks indicate that the available number of trials for this category limits the reliability of the analysis performed and clinical judgment is recommended. Color coding reflects statistical significance: blue shading indicates statistically significant effects; gray shading denotes obesity medications tested without significant effects. CVD, cardiovascular disease; KOA, knee osteoarthritis; Naltr-Bupr, naltrexone–bupropion; Phen-Topir, phentermine–topiramate.

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