Table 1 Primary endpoints for each subgroup of patients

Obesity management medication decision

Body weight management in obesity

No complications present

Total body weight loss (%)

At endpoint

3.0^a

4.8^a

4.2^a

8.8^a

8.7^a

16.5^a

At 52 weeks

2.1

4.8^a

7.0^a

8.8^a

10.7^a

14.8^a

At 53–104 weeks

2.8^a

4.8^a

4.3^a

8.8^a

10.1^a

16.5^a

Complications management in obesity

Fat mass diseases

OSAS

OSAS remission (OR)

NA

NA

NA

NA

NA

2.9^a

KOA

KOA improvement (WMD)

NA

NA

NA

NA

−8.6^a

NA

Sick fat diseases

Pre-diabetes

Normoglycemia restoration (OR)

NA

NA

3.25^a

NA

19.6^a

8.3^a

Type 2 diabetes

Diabetes remission (OR)

NA

2.3^a

6.8^a

NA

12.3^a

15.6^a

Cardiovascular disease

MACE incidence (OR)

A

0.88

NA

NA

0.78^a

NA

Heart failure

Hospitalization for heart failure (OR)

NA

NA

NA

NA

0.23^a

0.45^a

MASLD

MASH remission (OR)

NA

NA

NA

NA

2.0

11.8^a