Extended Data Fig. 5: Heatmap depicting relative levels (log fold change) of differentially expressed selected candidate genes associated with MASH and fibrosis in semaglutide-treated DIO-MASH mice (a) and CDA-HFD mice (b). | Nature Medicine

Extended Data Fig. 5: Heatmap depicting relative levels (log fold change) of differentially expressed selected candidate genes associated with MASH and fibrosis in semaglutide-treated DIO-MASH mice (a) and CDA-HFD mice (b).

From: Modulation of metabolic, inflammatory and fibrotic pathways by semaglutide in metabolic dysfunction-associated steatohepatitis

Extended Data Fig. 5

The liver transcriptome was probed against a selected set of genes involved in lipid metabolism, insulin signaling, FXR signaling, inflammation signaling, monocyte recruitment, hepatocellular cell death and stellate cell activation. Upregulated (red color gradient) and downregulated (blue color gradient) gene expression in individual pathways as compared to the corresponding control group. *P < 0.05 versus DIO-MASH vehicle (a) and CDA-HFD vehicle (b). P values corrected for multiple testing using the Benjamini and Hochberg method. CDA-HFD, choline-deficient L-amino acid-defined high-fat diet; DIO, diet-induced obesity; FXR, farnesoid X receptor; MASH, metabolic dysfunction-associated steatohepatitis; W, week.

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