Extended Data Fig. 7: Change in protein levels in participants with MASH treated with semaglutide compared with protein levels in healthy volunteers in an independent real-world observational cohort.
Gray-colored data points and error bars represent the full complement of aptamer-based SomaScan proteins; blue-colored points and error bars are those proteins significantly associated with semaglutide-induced MASH resolution; proteins of interest in the current work are highlighted in orange and green. The vertical axis represents the mediation effect on protein biomarkers from the SomaScan analysis with respect to semaglutide-induced MASH resolution. The horizontal axis displays the log2 fold changes in protein levels between healthy individuals and those with MASH in the independent CoCoMASLD cohort, while accounting for the effect of gender, age, body mass index and diabetes status.
