Fig. 3: 1H-fMRS voxel position and spectra.

a, Voxel center placement. b, Voxel density map across participants and sessions in Montreal Neurological Institute (MNI) space. Blue, placebo condition; orange, naltrexone. The shading of the contour lines represents the percentage (%) overlap at that point. c, Sample spectrum from averaged block for single participant with output of the fit (red) overlaid on the acquired spectrum (black). The estimated baseline is displayed under the spectrum in black. Plotted in units of parts per million (ppm). d, Combined spectra for single block across participants and conditions. Blue, placebo; orange, naltrexone. e, Combined spectra fit for single block across participants and conditions. Blue, placebo; orange, naltrexone.