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Cardiovascular diseases

Targeting triglyceride-rich lipoproteins in cardiovascular disease

Nature Medicine volume 31, pages 2492–2493 (2025)Cite this article

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Positive results from a first-in-human clinical trial validate the ANGPTL3–ANGPTL8 complex as a new therapeutic target for reducing triglycerides and, potentially, cardiovascular disease risk.

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Fig. 1: Identifying regulators of LPL in the metabolism of TRLs reveals potential therapeutic targets.

References

  1. Rader, D. J. N. Engl. J. Med. 392, 1740–1742 (2025).

    Article  CAS  PubMed  Google Scholar 

  2. Ginsberg, H. N. et al. Eur. Heart J. 42, 4791–4806 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hvid, K., Balling, M., Afzal, S. & Nordestgaard, B. G. Eur. J. Prev. Cardiol. https://doi.org/10.1093/eurjpc/zwaf203 (2025).

    Article  PubMed  Google Scholar 

  4. Gaudet, D. et al. Nat. Med. https://doi.org/10.1038/s41591-025-03830-4 (2025).

    Article  PubMed  Google Scholar 

  5. Ference, B. A. et al. JAMA 321, 364–373 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Chebli, J., Larouche, M. & Gaudet, D. Curr. Opin. Endocrinol. Diabetes Obes. 31, 70–77 (2024).

    Article  CAS  PubMed  Google Scholar 

  7. Dewey, F. E. et al. N. Engl. J. Med. 377, 211–221 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Rosenson, R. S. et al. Cardiovasc. Drugs Ther. https://doi.org/10.1007/s10557-024-07567-z (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Rosenson, R. S. et al. N. Engl. J. Med. 391, 913–925 (2024).

    Article  CAS  PubMed  Google Scholar 

  10. Chen, Y. Q. et al. J. Lipid Res. 61, 1203–1220 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Kumar, A. et al. Proc. Natl Acad. Sci. USA 122, e2420721122 (2025).

    Article  Google Scholar 

  12. Cummings, B. B. et al. Lancet 405, 1923–1934 (2025).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

A.B. receives research funding support from Amgen, Arrowhead, Eli Lilly, Ionis, Kaneka Medical, NewAmsterdam Pharma, Novartis and Regeneron and has received honoraria from Chiesi, Kaneka Medical, Ionis, Medscape, Novartis, and Regeneron.

D.J.R. is on scientific advisory boards for Alnylam, Bitterroot, Marea, Novartis and Verve.

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Authors and Affiliations

  1. Division of Translational Medicine & Human Genetics, University of Pennsylvania, Philadelphia, PA, USA

    Archna Bajaj & Daniel J. Rader

  2. Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA

    Daniel J. Rader

  3. Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Daniel J. Rader

Authors
  1. Archna Bajaj
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  2. Daniel J. Rader
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Correspondence to Daniel J. Rader.

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Bajaj, A., Rader, D.J. Targeting triglyceride-rich lipoproteins in cardiovascular disease. Nat Med 31, 2492–2493 (2025). https://doi.org/10.1038/s41591-025-03845-x

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