Extended Data Fig. 4: Effect of Vutrisiran on the Ratio of Early Diastolic Transmitral Flow Velocity to Lateral Early Diastolic Mitral Annular Tissue Velocity (E/e’) Over Time.

Mean values (±SEM) during follow-up are shown according to treatment assignment in the (a) overall (n = 620) and (b) vutrisiran monotherapy population (n = 321). Error bars represent the standard error of the mean.