Table 1 Baseline echocardiographic parameters according to treatment assignment
Echocardiographic parameter | Overall population | Monotherapy population | ||||
|---|---|---|---|---|---|---|
n | Placebo (n = 328) | Vutrisiran (n = 326) | n | Placebo (n = 199) | Vutrisiran (n = 196) | |
LV structure | ||||||
Mean LV wall thickness (mm) | 645 | 18.2 (2.7) | 18.2 (2.6) | 388 | 18.3 (2.9) | 18.2 (2.7) |
LVEDD (mm) | 642 | 42.7 (5.9) | 42.6 (5.8) | 387 | 42.7 (5.5) | 42.9 (5.6) |
LVEDV (ml) | 630 | 95.6 (29.0) | 93.9 (25.9) | 377 | 92.8 (25.0) | 91.1 (25.2) |
LVESD (mm) | 576 | 33.7 (6.1) | 33.7 (5.7) | 343 | 33.5 (5.8) | 33.3 (6.1) |
LVESV (ml) | 627 | 43.4 (23.2) | 43.0 (21.0) | 374 | 42.3 (20.4) | 42.4 (20.2) |
LV mass index (g m−2) | 637 | 180.8 (46.1) | 182.1 (44.2) | 382 | 185.7 (49.5) | 186.7 (46.8) |
LV systolic function | ||||||
LVEF (%) | 627 | 55.9 (12.4) | 55.6 (12.7) | 374 | 55.7 (12.1) | 54.8 (12.6) |
Absolute GLS (%) | 652 | 14.0 (3.5) | 14.0 (3.5) | 393 | 14.3 (3.5) | 14.0 (3.4) |
Stroke volume (ml) | 616 | 53.8 (19.0) | 50.7 (16.3) | 373 | 55.8 (19.6) | 51.2 (16.8) |
TDI lateral s’ (mm s−1) | 621 | 49.4 (16.1) | 49.5 (15.8) | 375 | 49.8 (15.7) | 50.1 (16.7) |
TDI septal s’ (mm s−1) | 630 | 42.0 (11.8) | 41.5 (12.6) | 383 | 42.3 (12.1) | 41.6 (13.1) |
LV diastolic function | ||||||
E/A ratio | 353 | 1.9 (1.0) | 2.1 (1.1) | 202 | 1.9 (1.0) | 2.1 (1.1) |
E wave (mm s−1) | 644 | 806.7 (199.3) | 804.0 (203.4) | 387 | 802.5 (184.1) | 814.1 (212.3) |
A wave (mm s−1) | 354 | 489.0 (229.2) | 461.4 (226.3) | 202 | 512.5 (235.6) | 488.8 (248.5) |
Deceleration time (ms) | 627 | 211.8 (55.5) | 214.3 (59.0) | 375 | 203.4 (50.7) | 209.7 (57.3) |
TDI lateral e’ (mm s−1) | 627 | 58.5 (20.5) | 61.4 (22.6) | 380 | 58.3 (19.8) | 61.2 (22.6) |
TDI septal e’ (mm s−1) | 632 | 41.3 (12.1) | 42.9 (14.3) | 383 | 42.1 (12.7) | 42.6 (14.0) |
E/e’ lateral | 620 | 15.3 (6.3) | 14.8 (6.7) | 321 | 15.3 (5.7) | 15.1 (7.1) |
E/e’ septal | 625 | 21.1 (8.3) | 20.5 (7.9) | 377 | 20.5 (6.9) | 20.9 (8.0) |
E/e’ average | 612 | 18.2 (6.1) | 17.7 (6.6) | 367 | 18.0 (5.6) | 18.0 (6.8) |
LA size and function | ||||||
LA diameter (mm) | 632 | 41.3 (4.8) | 41.7 (5.8) | 378 | 40.9 (4.5) | 42.0 (6.1) |
LA volume index (ml m−2) | 638 | 38.4 (10.4) | 39.0 (10.3) | 383 | 38.7 (9.7) | 40.4 (10.4) |
TDI lateral a’ (mm s−1) | 403 | 42.6 (20.5) | 43.2 (22.3) | 242 | 42.7 (19.8) | 45.5 (24.1) |
TDI septal a’ (mm s−1) | 345 | 40.8 (19.1) | 39.8 (18.2) | 203 | 42.0 (19.1) | 42.1 (19.7) |
RV and pulmonary pressure | ||||||
RV free wall thickness (mm) | 457 | 8.3 (1.9) | 8.1 (1.8) | 283 | 8.6 (2.0) | 8.4 (1.9) |
RV end-diastolic area (cm2) | 558 | 22.3 (6.1) | 21.6 (5.1) | 325 | 21.4 (5.1) | 21.6 (5.1) |
RV end-systolic area (cm2) | 554 | 13.8 (4.5) | 13.0 (3.6) | 322 | 13.4 (3.6) | 13.1 (3.7) |
RV S’ (mm s−1) | 625 | 93.5 (27.2) | 94.0 (26.6) | 374 | 94.8 (28.1) | 93.4 (28.1) |
TR velocity (m s−1) | 535 | 2.5 (0.4) | 2.6 (0.5) | 308 | 2.5 (0.4) | 2.5 (0.5) |
Maximal IVC diameter (mm) | 508 | 20.2 (5.5) | 20.4 (5.3) | 311 | 20.0 (5.2) | 20.5 (5.4) |
