Extended Data Fig. 2: Association between IgG levels to conserved antigens and protection from culture confirmed S. pyogenes events.

(a)The proportion of visits (n = 4677) with IgG levels above each threshold with a culture-confirmed S. pyogenes event within 45 days. IgG levels were measured from n = 1,987 visits and assumed to remain constant between measurement. (b) Logistic regression analysis with mixed effects to explore the relationship between IgG level and event within 45 days. The blue line shows the fitted regression model grey shading represents the 95% confidence intervals for model predictions. Odds ratios per log₁₀ IgG level increase, 95% confidence intervals, and p-values for the logistic regression model are displayed.