Fig. 4: The causal link between circulating markers and the immune response of PLHIV.
From: Genetic and molecular landscape of comorbidities in people living with HIV
a,c, Top genes (a) and proteins (c) with the most significant Mendelian randomization (MR) links to cytokine responses. Significance was estimated by IVW MR with sensitivity checks (Methods). Color indicates the effect calculated by IVW MR. *P < 0.05, **P < 0.01, ***P < 0.001. b,d,e, Examples of regulators of immune response in PLHIV. All effects and P values were calculated by IVW MR. Only significant effects (P < 0.05 and sensitivity checks passed) are shown. b, All cytokine responses regulated by LINC00173. d, Responses to the HIV envelope regulated by IL-17D. e, All the regulators of CCL3 responses to the HIV envelope. Schematics were created with BioRender.com.
