Fig. 5: The NLRP12 locus and the multi-omics landscape of the inflammasome in PLHIV.
From: Genetic and molecular landscape of comorbidities in people living with HIV
a, Top association between LFs and genome-wide variants by QTL mapping. b, LocusZoom plot of the association between the NLRP12 locus and LF6. c, Number of GWs (P < 5 × 10−8) associations replicated in the validation cohort (P < 0.05) between the missense variant rs34436714 and different omics layers. d, Association between rs34436714 and an inflammasome score computed at gene expression and protein levels. Discovery cohort, n = 1,075. Two-sided pairwise Wilcoxon rank-sum test, *P < 0.05, **P < 0.01, ***P < 0.01. Box plots show the median (center), first and third quartiles (bounds) and 1.5 times the interquantile range (whiskers). e, Correlation between AMP and taurine abundance and the inflammasome score computed at gene expression and protein levels. Pearson’s correlation. f, Correlation between LF6 and two monocyte proportions. Pearson’s correlation. The gray shaded area indicates the 95% confidence interval. g, Schematic of the hypothesized mechanism. Schematics were created with BioRender.com.
