Extended Data Fig. 1: Disease classification of multiple sclerosis.

Consensus definitions from 1996 and in its ‘2013 revisions’ and variants of it as used in indication statements in US packet inserts, summaries of product characteristics by the European Medicines Agency and in scientific publications. Relapsing forms of multiple MS include CIS, RRMS, and aSPMS in adults. aRRMS, active RRMS; aSPMS, active SPMS; CIS, clinically isolated syndrome; haRRMS, highly active RRMS; IPPMS, late PPMS (as opposed to ‘early PPMS’); MS, multiple sclerosis; naSPMS, non-active SPMS (as opposed to ‘active SPMS’); PMS progressive MS (SPMS + PPMS); PPMS, primary progressive MS; PRMS, progressive relapsing MS; RRMS relapsing remitting MS; SPMS, secondary progressive MS; «progression in MS » refers to the process of progression, which occurs in all subtypes of MS.