Extended Data Fig. 6: Eight-state modelling with no imputation of missing data.

Analysis based on non-missing data, that is analysis without data imputation performed by mapping data to annual visits (based on the availability of annual MRI scans): (a) clinical states and (b) transition matrix between states. The frequency of subclinical disease activity is underestimated in this model due to the remapping of relapses from other timepoints were they occurred to the annual visits where MRI scans are available. Overall, the disease states and transition patterns observed were similar to those in the main model.