Extended Data Fig. 1: Workflow schematic for modelling and mapping the global risk of selection and spread of pfhrp2/3 deletions.

a) Estimation of selection coefficients from stochastic model simulations. b) Generating training data using simulation studies that feed into c) a statistical model for estimating selection coefficients. d) The final model is used to estimate the risk posed by pfhrp2/3 deletions using collated subnational covariates and parameters from model fitting exercises.