Extended Data Fig. 3: Expression of T cell activation and proliferation markers. | Nature Medicine

Extended Data Fig. 3: Expression of T cell activation and proliferation markers.

From: Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled phase 1b study

Extended Data Fig. 3

Change in the expression of proliferation and activation markers A) Ki67, B) HLA-DR, and C) Granzyme B+ on CD8+ memory cells relative to baseline and correlation between plasma HIV RNA and D) Ki67, E) HLA-DR, and F) Granzyme B in stage I and stage II of the study. Spearman correlations were conducted grouping the entire dataset. T cell memory subsets were assessed using markers CD45RO and CCR7. Naive cells were identified as CD45RO − CCR7 + , central memory cells were identified as CD45RO + CCR7 + , TM/EM cells were identified as CD45RO + CCR7 − , TE cells were identified as CD45RO − CCR7− cells, and memory cells were identified as CD45RO+ cells. HLA-DR, human leukocyte antigen DR; Ki67, markers antigen Kiel 67; PBO, placebo; TM/EM, transient/effector memory.

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