Extended Data Fig. 3: Expression of T cell activation and proliferation markers.

Change in the expression of proliferation and activation markers A) Ki67, B) HLA-DR, and C) Granzyme B+ on CD8+ memory cells relative to baseline and correlation between plasma HIV RNA and D) Ki67, E) HLA-DR, and F) Granzyme B in stage I and stage II of the study. Spearman correlations were conducted grouping the entire dataset. T cell memory subsets were assessed using markers CD45RO and CCR7. Naive cells were identified as CD45RO − CCR7 + , central memory cells were identified as CD45RO + CCR7 + , TM/EM cells were identified as CD45RO + CCR7 − , TE cells were identified as CD45RO − CCR7− cells, and memory cells were identified as CD45RO+ cells. HLA-DR, human leukocyte antigen DR; Ki67, markers antigen Kiel 67; PBO, placebo; TM/EM, transient/effector memory.