Extended Data Fig. 3: Change in lipid and lipoprotein parameters.

Least squares (LS) mean (95% confidence interval) percent change from baseline in apolipoprotein B (apoB, upper left panel), non-high-density lipoprotein (HDL) cholesterol (upper right panel), HDL cholesterol (lower left panel) and triglycerides (lower right panel) in patients treated with placebo or obicetrapib. Sample size: n = 118 (placebo), n = 236 (obicetrapib) representing biological replicates (individual patients with heterozygous familial hypercholesterolemia on maximally tolerated lipid-lowering therapy).