Supplementary Figure 10: Glmnet cross-validation curves and correlation with reference.
From: SAVER: gene expression recovery for single-cell RNA sequencing
Poisson Lasso regression cross-validation plots from Glmnet and correlation with Zeisel reference plots for five genes from the 5% efficiency dataset. The x-axis represents the size of the shrinkage penalty in the LASSO regression. The dotted vertical line represents the model with the lowest cross-validation error. The horizontal line is the observed correlation with the reference and the black points represent the correlation of the SAVER estimate with the reference at each value of the shrinkage penalty. The red points in the cross-validation plot represents the mean cross-validation error as measured by Poisson deviance and the error bars represent ± 1 standard deviation. SAVER correlation with the reference is approximately maximized when using the model with the lowest cross-validation error.
