Supplementary Figure 8: Differentially expressed (DE) genes in an RNA-seq experiment.
From: An enhanced CRISPR repressor for targeted mammalian gene regulation
(a-c) Shown are log2 fold change (FC) versus average log2 count per millions (CPM) for dCas9, dCas9-KRAB and dCas9-KRAB-MeCP2 relative to the negative control. Genes with no fold change are marked in black, DE genes are marked in grey, and DE genes above log2 FC of 1.5 threshold are marked in red. Positive log2 FC represents transcriptional activation while negative values indicate repression. (d) Shown is a summary of the number of DE genes showing up- or down-regulation with log2 FC > 1.5 in different groups. (Methods associated with this figure are described in Supplementary Note 2).
