Supplementary Figure 13: Performance of different dCas9 repressors in pooled essentiality screens.
From: An enhanced CRISPR repressor for targeted mammalian gene regulation
Shown are rank-ordered genes identified from sgRNA enrichment analysis performed using MAGeCK analysis pipeline in (a) HAP1 (day 14), (b) SH-SY5Y (day 14), and (c) HEK293T (day 14) with the indicated repressors. Genes were plotted according to the p-values obtained from MAGeCK and marked the FDR threshold at 0.25 (25%). The genes are colored by essentiality (red indicates essential genes and gray indicates non-essential genes). The horizontal lines indicate the FDR threshold and where there is no line indicates no genes were identified at the given threshold.
