Supplementary Figure 5: B cell phenotype and antigen-specific immune responses after KLH immunization in HIS mice. | Nature Methods

Supplementary Figure 5: B cell phenotype and antigen-specific immune responses after KLH immunization in HIS mice.

From: A human immune system mouse model with robust lymph node development

Supplementary Figure 5

(a) FACS analysis of mature human B cells (gated on hCD45+mCD45−CD19+ cells) from HIS mice. Representative analysis from 10 independent mice with similar results. (b) KLH specific IgG ELISA results from sera and (c) IFN-γ ELIspot results from splenocytes of KLH-immunized HIS mice in 2 independent experiments. (n = 4 mice/group, centre values represent mean, and error bars denote s.e.m.).

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