Supplementary Figure 2: Mutation-effect predictions from generative models can be generalized to unseen sequences.
From: Deep generative models of genetic variation capture the effects of mutations
(above) Spearman ρ of mutation effect prediction of β-lactamase7 of each of the three generative models (N = 4788). Sequences with a normalized hamming distance greater than 0.53, 0.6, 0.8, and 0.95 with respect to the reference sequence are removed from the alignment before model fitting and inference. The distribution of hamming distances of the alignment and the cutoff of inclusion into each alignment is shown below.
