Supplementary Figure 13: Fluorescence signal of single labeled telomeres increased after CASANOVA activation.
From: Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9
We calculated telomere fluorescence by multiplying the area of the fluorescent spot with its mean fluorescence intensity. Box plots show the median (center line) and first and third quartiles (box edges), 1.5× the interquartile range (whiskers) and individual data points (dots). Data correspond to the experiment described in Fig. 2d,e. The total number of telomeres analyzed is indicated. ***P < 2.2 × 10–16 by a two-sided Wilcoxon rank-sum test.
