Supplementary Figure 11: The increase in spike rate in target cells is larger than that in background cells after closed-loop photostimulation.

Bootstrap test on the change in the inferred spike rate in the target cells and background cells: increase in activity of the target cells was greater than that of 97% ± 2.7% (mean ± s.e., n = 6 animals) of the bootstrap samples of the background cells. Gray area shows the distribution of the change in inferred spike rate of 3,000 randomly selected samples (groups of all detected cells in the field of view (excluding the trigger cell) with the same number of cells as in the targets group); red lines are the upper limit of the 95% bootstrap confidence interval; black arrows locate the average change in the target cells in the distributions.