Supplementary Figure 4: Effect of exclusion of a single dataset from generic or YETI integrations.
From: Interpretation of an individual functional genomics experiment guided by massive public data
Distribution of the Dataset Specificity Score for including the dataset, excluding it, and using YETI are shown. The center line represents the median, the lower and upper hinges indicate the first and third quartiles, the upper whisker extends to the largest value less than 1.5 x IQR and the lower whisker extends to the smallest value at most 1.5 x IQR. 10 of the 362 GEO datasets used for evaluation in Fig. 2 were chosen at random to be excluded from or included into the generic integrations that were evaluated over the MeSH terms relevant to each dataset (See Supplemental Online Methods). YETI achieved significantly improved dataset specificity over generic integration (**p = 3.1 x 10-4, one-tailed paired t test), and including the dataset of interest in the generic integration had no effect on specificity (p = 0.87, one-tailed paired t test). N.S. = not significant.
