Supplementary Figure 11: Array-based multiplexing enhances AsCas12a-VPR-mediated transcriptional activation.
From: Multiplexed orthogonal genome editing and transcriptional activation by Cas12a
Relative mRNA expression after co-transfection of HEK293T cells with AsCas12a-VPR and crRNA arrays. Multiplex expression of three 15-nt guides expressed from a single array versus respective single crRNAs targeting the promoter of TTN, or NPY1R respectively. Mean ± s.d.; N = 3 independent experiments.
