Synthetic small molecules can form liquid-phase condensates and simultaneously sequester intracellular enzymes.
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Research papers
Boija, A. et al. Transcription factors activate genes through the phase-separation capacity of their activation domains. Cell https://doi.org/10.1016/j.cell.2018.10.042 (2018).
Feng, Z., Wang, H. & Xu, B. Instructed assembly of peptides for intracellular enzyme sequestration. J. Am. Chem. Soc. 140, 16433–16437 (2018).
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Tang, L. Artificial biomolecular condensates. Nat Methods 16, 23 (2019). https://doi.org/10.1038/s41592-018-0288-4
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DOI: https://doi.org/10.1038/s41592-018-0288-4