Supplementary Figure 7: Microtubule perturbation affects actin cortex and SNACS.
From: Noninvasive monitoring of single-cell mechanics by acoustic scattering
a, SNACS measured from L1210 cells treated with microtubule-affecting drugs: nocodazole (Noc, 1 μg/ml, n = 760 cells, P = 2.8 × 10–16) and Taxol (25 μM, n = 511 cells, P = 0.12). Statistical comparisons (two-sided Welch’s t-test) were made to DMSO control (0.1%, n = 718 cells). Boxes indicate the interquartile range, squares represent means, and whiskers extend to the 5th and 95th percentiles; ****P < 0.0001; n.s., not significant. b, Representative images of actin cortex from live L1210 cells expressing LifeAct–RFP F-actin probe before (top) and after (bottom) treatment with nocodazole 1 μg/ml (n = 7 fields of views). Scale bars, 10 μm.
