Supplementary Figure 11: Calculated magnetic field dependence of R2 for 13CF and 19FC nuclei in various 19F-substituted nucleobases.

Blue triangles represent the R2 of decoupled resonances, and red squares represent those of TROSY resonances. The relaxation rates are calculated for the respective 19FC-bearing nucleobase assumed to be incorporated into a nucleic acid with a rotational correlation time (τc) of 25 ns. The points are connected by a dashed line to provide visual clarity.