Supplementary Figure 11: Structural features of dominant negative fragments contributing to inhibitory activity of yeast phosphoglycerate kinase.
From: High-throughput identification of dominant negative polypeptides in yeast
a, Coverage chart for yeast Pgk1 showing two dominant negative regions, as well as several local minima within these regions. b, Crystal structure of the yeast Pgk1 protein (PDB 1QPG), with N-terminal domain shown in light gray and C-terminal domain shown in dark gray. Short segments colored in red correspond to the local minima in the coverage chart (dashed lines); these are found in close physical proximity and in similar locations within four β-strands.
