Supplementary Figure 9: Association between the DNA and the RNA profiles.
From: Integrated transcriptomic–genomic tool Texomer profiles cancer tissues
a–d, Plotted in three rows are the Pearson’s correlation coefficients between bulk DNA count and bulk RNA count, between Texomer-transformed tumor DNA (TT-DNA) profile and bulk RNA count, and between TT-DNA and TT-RNA profile at the germline SNP and somatic SNV sites, for allele-agnostic analysis of the BRCA samples (a) and the SKCM samples (c) or allele-specific analysis in the BRCA samples (b) and the SKCM samples (d). The black horizontal line in the box is the median; the top and bottom horizontal lines denote 95% confidence interval of the median; the top and bottom of box are the 25th and 75th percentiles for the data. e,f, The proportion of variance from the same three pairs of sources were plotted for allele-agnostic (e) and allele-specific analysis (f) in the SKCM samples. P value determined by one-tailed t test (BRCA: n = 832; SKCM: n = 465).
