Supplementary Figure 12: Characterization of variants with negative DACRE scores.
From: Integrated transcriptomic–genomic tool Texomer profiles cancer tissues
a,b, Average DNA methylation levels of genes with negative (black arrows) and positive (red arrows) DACRE scores in 832 BRCA (a) and 465 SKCM (b) samples, compared with a background distribution (gray histogram) constructed from randomly selected gene sets. c, The DACRE, ASCNs and ASELs of the six TCGA SKCM samples containing heterozygous TERT exonic variants. d, DNA methylation levels in the TERT promoter of the TCGA samples. e, RNA expression levels of TCGA SKCM samples (n = 465). TCGA-EE-A2M5 and TCGA-FR-A726 are labeled with blue and red asterisks, respectively. The black horizontal line in the box is the median; the top and bottom horizontal lines denote 95% confidence interval of the median; the top and bottom of box are the 25th and 75th percentiles for the data.
