Supplementary Figure 13: Somatic SNVs with positive DACRE scores in TSGs.

a, Heat map characterizing the DACRE, ASELs of the variant alleles (ASEL_variant) and the wild-type alleles (ASEL_wildtype) for each somatic mutation detected in TP53 in the BRCA samples. Values plotted are summed over carrier samples. High-frequency mutations are more likely to have more extreme scores. Mutations labeled starting with ‘chr’ are noncoding mutations. GATA3:p.M294K gain of function predicted by DACRE-scan. b, Three samples harboring GATA3:p.M294K. The ASCNs (left panel) and the ASELs (right panel) estimated for the wild-type and variant alleles in the BRCA samples carrying the mutation. c, Deconvoluted total tumor expression levels (TELs) and the bulk expression levels (FPKMs) among the BRCA samples harboring germline or somatic variants in GATA3 (n = 291). Asterisks (*) indicate the three samples carrying p.M294K. The black horizontal line in the box is the median; the top and bottom horizontal lines denote 95% confidence interval of the median; the top and bottom of box are the 25th and 75th percentiles for the data. d, Breakdown of DACRE scores of CDH1 somatic SNVs in the BRCA samples. e,f, The ASCNs (left panel) and the ASELs (right panel) estimated for the wild-type and the variant alleles in the BRCA samples containing CDH1:p.E243K (e) and CDH1:p.R335* (f).