Supplementary Figure 15: WES/WTS joint characterization of functional somatic mutations in TCGA data.
From: Integrated transcriptomic–genomic tool Texomer profiles cancer tissues
a,b, Somatic SNVs were first prioritized on the basis of functional impact scores calculated by a set of widely used functional annotators, and then further filtered by the bulk WTS count (>20) or the DACRE score (>0). The pink and blue bars show the fractions of patient samples in 832 BRCA (a) and 465 SKCM (b) patient samples with increased proportions of known functional variants in the OncoKB database after WES/WTS profiling. d–f, Level of accuracy improvement in the BRCA (c,d) and the SKCM samples (e,f) after applying DACRE score > 0 (c,d) and WTS read count > 20 (e,f) filtering. ‘None’ represents no or negative improvement, 0% represents a level of improvement between 0% and 1%, 1% represents a level of improvement between 1% and 10%, etc.
