Supplementary Figure 1: Illustration of Texomer deconvolution steps. | Nature Methods

Supplementary Figure 1: Illustration of Texomer deconvolution steps.

From: Integrated transcriptomic–genomic tool Texomer profiles cancer tissues

Supplementary Figure 1

Texomer iteratively estimates ASCN (gray and green boxes), tumor purity (αD), ITH scores from the bulk WES data (steps 1–4), and tumor purity (αR) and ASELs from the bulk tumor WTS data (step 5). It then probabilistically classifies variants into three categories (step 6): ASCN-concordant (ASEL ≈ ASCN), ASCN-discordant high (ASEL > ASCN) or low (ASEL < ASCN).

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