Supplementary Figure 2: Quantification of ITH.
From: Integrated transcriptomic–genomic tool Texomer profiles cancer tissues
a, Definition of ITH scores: the difference (purple) between the probability density of the ASCNs estimated from somatic variants and that from germline variants. b, Example TCGA sample of a low ITH score. c, Estimated ASCNs of the germline SNP alleles (red and green boxes) and somatic SNV alleles (blue dots) of the sample in b. Plotted as boxes are integerized ASCN segments of the major (red) and minor (green) alleles. d, Example TCGA sample of a high ITH score. e, Estimated ASCNs of the sample in d.
