Supplementary Figure 5: Accuracy of Texomer transformation.

a, Comparison of inferred tumor purity values versus simulated ground truth for 5 methods: Texomer, ASCAT, TITAN, sequenza, and FACETs. b, Average absolute errors between simulated and inferred tumor purity by the five methods. c, Average absolute errors between simulated and inferred DNA copy number by the five methods, as well as average absolute errors between simulated and inferred RNA expression levels by Texomer. d, Pearson’s correlation coefficients between the Texomer transformed tumor ASELs and single-cell gene expression levels in 11 breast cancer tissues (BC01–BC11). e, Pearson’s correlation coefficients between the bulk tumor WTS read counts and single-cell gene expression levels, in contrast to d. P value determined by one-tailed t test (n = 11). The black horizontal line in the box of d and e is the median; the top and bottom horizontal lines denote 95% confidence interval of the median; the top and bottom of box are the 25th and 75th percentiles for the data.