Supplementary Figure 6: Evaluation of tumor purity and ITH scores on TCGA BRCA and SKCM data.
From: Integrated transcriptomic–genomic tool Texomer profiles cancer tissues
a, Pearson’s correlation coefficients between tumor purities estimated by Texomer, ASCAT, sequenza, TITAN and FACES, and tumor purities estimated by ABSOLUTE, ESTIMATE, DNA methylation and pathologist review on TCGA BRCA (n = 832) and SKCM data (n = 465). b,c, Survival analysis of patients with BRCA luminal B subtype (b) and SKCM (c) based on heterogeneity score. ‘High,’ ITH score ≥ 0.5; ‘Low,’ ITH score < 0.5. P value determined by two-sided log-rank test. d,e, PD-L1 expression levels with respect to heterogeneity score in TCGA BRCA (d) and SKCM (e) patients. P value determined by two-tailed Mann–Whitney test (BRCA: n = 832; SKCM: n = 465). The black horizontal line in the box is the median; the top and bottom horizontal lines denote 95% confidence interval of the median; the top and bottom of box are the 25th and 75th percentiles for the data.
