Extended Data Fig. 5: Single-read epigenetic assessment on CTCF binding sites.

a, Heatmaps of lengths of runs of accessible chromatin calls on individual reads with respect to distance from CTCF binding sites, separated based on presence of ChIP-seq peaks. b, Density distributions of inaccessible runs at the CTCF binding sites, showing that sites without CTCF binding have long inaccessible runs suggesting nucleosome binding while those with CTCF binding have short inaccessible runs (sub-nucleosomal footprints) suggesting CTCF binding. c, Inaccessible runs were classified as either sub-nucleosomal or nucleosome binding depending on their lengths based on mixed Gaussian models.