Extended Data Fig. 5: RNA-protein correlations.
From: Joint probabilistic modeling of single-cell multi-omic data with totalVI
a, b, 2d density plots of Pearson correlations between all RNA and protein features in the SLN111-D1 dataset as well as 100 additional genes whose expression was randomly permuted. Correlations between all proteins and the randomly permuted genes are colored in red. Raw correlations were calculated between log library-size normalized RNA and log(protein counts + 1). (a), Naive totalVI correlations were calculated between totalVI denoised RNA and totalVI denoised proteins. (b), totalVI correlations were calculated between denoised RNA and proteins sampled from the posterior (Methods). c, Pearson correlations between each protein and its encoding RNA for all proteins with a unique encoding RNA, colored by the mean probability foreground of the protein across all cells. totalVI correlations were calculated as in (b) and raw correlation were calculated as in (a, b). d-f, Same as (a-c), but for Spearman correlations.
