Extended Data Fig. 10: totalVI identifies correlated modules of RNA and proteins that are associated with the maturation of transitional B cells.
From: Joint probabilistic modeling of single-cell multi-omic data with totalVI
a, UMAP of the totalVI latent space colored by totalVI RNA expression of Rag1. b, totalVI RNA expression of Rag1 as a function of 1 - Z16 (the totalVI latent dimension associated with transitional B cells). c, totalVI Spearman correlations in mature B cells between the same RNA and proteins as in Fig. 5h. Features were hierarchically clustered within mature B cells. d, Histogram of Spearman correlations between each feature in (a) and 1 - Z16 (n = 2,735 cells).
