Supplementary Figure 6: Variant allele frequency (VAF) distributions for somatic variants called from whole exome sequencing data for the 32 fibroblast lines. | Nature Methods

Supplementary Figure 6: Variant allele frequency (VAF) distributions for somatic variants called from whole exome sequencing data for the 32 fibroblast lines.

From: Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes

Supplementary Figure 6

The grey lines indicate the minimum allele-frequency threshold (0.05) used for variants for this analysis (Methods). The blue lines indicate the model (neutral/selected) inferred by SubClonalSelection (shading 95% confidence interval). Donors with a selection probability below 0.3 are classified as ‘neutral’, above 0.7 as ‘selected’. Donors which are neither ‘selected’ nor ‘neutral’ remain ‘undetermined’. High confidence ‘selected’ lines (selection probability >0.7 and >100 somatic variants) are: joxm, wahn, garx, vass, ualf, euts, pipw, oilg, feec, fikt, qolg, and puie.

Back to article page