Supplementary Figure 12: Gene set enrichment results for fibroblast data from n=32 lines.
From: Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes
(a) Heatmap showing Spearman correlation between gene set enrichment results for the 16 most frequently enriched MSigDB Hallmark gene sets across 31 lines. Colour indicates the correlation between pairs of gene sets and is only shown if the correlation is significant (P < 0.05). (b) Heatmap showing proportion of overlap in genes between pairs of gene sets (matching those in left panel). (c) Heatmap showing the direction (first listed clone relative to second listed clone; in colour) and strength of enrichment (-log10(P) as degree of shading) for Hallmark gene sets tested with camera (Methods) for all pairwise comparisons between clones across n=31 lines. Gene sets that are significantly enriched at an FDR threshold of 5% are indicated with dots. Gene sets are shown if significant in at least one line and are ordered by number of lines in which they are significant.
