Supplementary Figure 3: Simulation results evaluating the inferred relax (error) rate in the configuration of variants in the guide clonal tree.
From: Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes
(a) The estimated relax rate as a function of the simulated error rates. Errors are simulated by uniformly swapping the mutation states in the configuration matrix of the guide clonal tree, which means that a clone may contain false mutations in the guide clonal tree provided to cardelino (except in the case of the base clone which has no mutations under any simulation conditions). (b) The estimated relax rate across different fractions of variants that have wrong branch configuration. Errors are added by swapping branches for variants.
