Supplementary Figure 5: Resolving IgG oligomers based on single ion intensities. | Nature Methods

Supplementary Figure 5: Resolving IgG oligomers based on single ion intensities.

From: Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry

Supplementary Figure 5

A Conventional native MS spectrum of IgG1-RGY. B Detailed view of the spectrum in A, showing the exact overlap between two charge states from the trimer (42+) and tetramer (56+) distributions at 10,649 m/z. C Single particle CD-MS spectrum of IgG1-RGY. D. Detailed view of the same region as in B, showing complete resolution of the coinciding trimer and tetramer charge states in the intensity dimension.

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