Extended Data Fig. 2: The embryonicdevelopment rates for BE3 and BE3 variants. | Nature Methods

Extended Data Fig. 2: The embryonicdevelopment rates for BE3 and BE3 variants.

From: A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

Extended Data Fig. 2

a, The blastocyst rate of BE3 and BE3 variants with sgRNA-D. All values are presented as mean ± s.e.m. b, The blastocyst rate for BE3-hA3A and BE3-FNLSwith additional sgRNAs. All values are presented as mean ± s.e.m. n = 3 biologically independent samples for each group.

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