Extended Data Fig. 10: Detailed methylation analysis of MGM2 sample.
From: Discovering multiple types of DNA methylation from bacteria and microbiome using nanopore sequencing
(a) Methylation binning using automated methylation features selection (without precise methylation motif discovery; Methods). Methylation features are projected on two dimensions using t-SNE. Contigs are colored per defined bin with point sizes matching contig length according to the legend. Bin 1, 3, 4, and 5 were defined using DBSCAN. The other bins are composed of one or two contigs and were manually defined after de novo methylation motif discovery. (b) Methylation binning using de novo discovered motifs on each bin found in a (Methods). Methylation features computed from de novo discovered motifs are projected on two dimensions using t-SNE. Contigs are colored per bin as described in a.
