Fig. 4: Prediction success and CPU times for the ten top-ranking binding predictors in the DisProt-binding dataset.
From: Critical assessment of protein intrinsic disorder prediction
a, The reference used (DisProt-binding, n = 646 proteins) in the analysis and how it was obtained. b–g, Performance of predictors expressed as maximum F1-score across all thresholds (Fmax) (b) and AUC (e) for the ten top-ranking methods (light gray) and baselines (white), and distribution of execution time per target (c,f) using the DisProt-binding dataset. b,e, The horizontal line indicates, respectively, Fmax and AUC of the best baseline. d,g, Precision–recall (d) and ROC curves (g) of the ten top-ranking methods and baselines using the DisProt-binding dataset, with level curves of F1-score and balanced accuracy, respectively. c,f, boxplots are defined as follows: the middle value of the dataset is the median (Q2/50th percentile) and box boundaries are the first quartile (Q1/25th percentile) and third quartile (Q3/75th percentile), respectively; maximum is Q3 + 1.5 × (Q3 – Q1) and minimum is Q1 – 1.5 × (Q3 – Q1). Outliers are hidden for clarity. c,f, Magenta dots indicate that the entire distribution of execution times is <1 s.
