Fig. 1: In silico Hi-C, SPRITE and GAM average contact maps match experimental data.
From: Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin
a, Illustration of computational experiments. An ensemble of single-molecule 3D structures of the polymer model of the DNA locus of interest is derived from bulk Hi-C data using the the PRISMR procedure27 and polymer physics simulations. b, The model 3D conformations, inferred from Hi-C data only, return average contact maps (bottom) that can be compared to Hi-C and independent SPRITE and GAM experimental data (top) in the study of the Sox9 locus (chr11:109–115 Mb, mm9) in mESC. Experimental Hi-C and SPRITE maps are derived from bulk data10,19, while GAM data are from a new dataset constructed from 1,122 F123 cells (Methods) and, correspondingly, the in silico maps. The color scale represents the percentiles of each dataset. Values of Spearman correlation rs between model and experiment are reported. Pearson and HiCRep correlations are reported in Supplementary Table 1a.
