Extended Data Fig. 5: The distribution of the target-strand editing. | Nature Methods

Extended Data Fig. 5: The distribution of the target-strand editing.

From: Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors

Extended Data Fig. 5

a, Signal distribution of Detect-seq. C-to-T mutations herein reflect non-target-strand edits, while G-to-A mutations are target-strand edits. b, Distribution of edited cytosines on the target strands. The pRBS region for off-target sites of VEGFA_site_2 sgRNA are indicated by the dashed lines. Count PAM as positions 21–23.

Source data

Back to article page