Extended Data Fig. 10: Potential Therapeutic Targets to Overcome COVID-19 Induced Tissue Damage.
From: Systematic investigation of cytokine signaling activity at the tissue and single-cell levels
a, Target genes of cytokines with elevated activities among severe patients. Arrow-headed edges indicate up-regulation, and flat-headed edges indicate down-regulation. For each cell type, red square nodes represent cytokines with high activity scores among severe patients, and blue diamonds represent anti-inflammatory signals with low activities. The network only includes targets whose expression values are significantly higher compared between severe and mild patients, and between disease and healthy controls. b, Example of gene expression in different patient groups. The violin plots present gene expression distributions in patient groups, smoothed by a kernel density estimator. Examples from lavage macrophages45 are in the left, and peripheral blood neutrophils46 are in the right. Y axis indicated values from individual cells.
